WELCOME TO GUDIPATI LAB!

We primarily use Caenorhabditis elegans as a model system to understand the functions of evolutionarily conserved DPPIV (DiPeptidyl Peptidase IV) proteases. We aim to decipher the catalytic activity-dependent functions by identifying their substrate repertoire and understanding their role in, but not limited to, the silencing of repetitive DNA sequences and "selfish" genetic elements such as transposons and the maintenance of the genome. We characterize the endogenous complexes comprised of these proteases without altering the stoichiometry in order to understand their catalytic activity-independent functions.

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We use advanced proteomics, Next Generation Sequencing, genome editing (CRISPR/Cas9) along with standard molecular biology and biochemistry approaches to address the above questions.

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If you are interested, motivated, and curious to understand deeply the biology of these proteases and want to be part of our team, please reach out to us.